Zantac 360°® — with the Active Ingredient, Famotidine

Zantac 360° is formulated with the active ingredient, famotidine — an H2-receptor antagonist (H2RA) — to both prevent and relieve your patients’ heartburn fast, with just one pill.

Famotidine is an FDA-approved safe and effective medication1 that’s clinically proven to prevent heartburn and provide fast relief and long-lasting acid control1,2 — for up to 12 hours*,2,3,4,5,6. Available in two strengths and offering flexible OTC heartburn control, recommend Zantac 360° today for the short-term management of occasional heartburn.

Zantac 360º: Fast and Long-Lasting

 

Zantac 360° Maximum Strength

Zantac 360° Original Strength

Active Ingredient

Famotidine, 20 mg

(acid reducer)

Famotidine, 10 mg

(acid reducer)

Formulation

Tablet (square, yellow)

Tablet (round, pink)

Patient Population

Adults and children 12 years and older

Adults and children 12 years and older

Onset for Relief

Take after onset of heartburn symptoms for fast heartburn relief

Take after onset of heartburn symptoms for fast heartburn relief

Onset for Prevention

Take as little as 10 minutes before eating or drinking to prevent heartburn

 

Take as little as 15 minutes before eating or drinking to prevent heartburn

 

Duration

Acid control lasts up to 12 hours*

Acid control lasts up to 12 hours*


*Acid control does not correlate to symptom relief.

Maximum Strength Zantac 360 package
Original Strength Zantac 360 package

Zantac 360º Can Prevent or Relieve Heartburn Fast with Famotidine

Zantac 360° contains famotidine, the #1 doctor recommended active ingredient,* and is a highly selective and long-acting H2RA that prevents heartburn when taken as little as 15 minutes before eating or drinking and relieves heartburn fast.1 Famotidine selectively targets and blocks H2 receptors on parietal cells in the stomach to decrease gastric acid production.5,8,9

Clinical studies show that famotidine, the active ingredient in Zantac 360º, can control stomach acid for up to 12 hours, day or night.†,2,3,4,5,6 Studies also show that both famotidine 10mg (Zantac 360º Original Strength) and 20mg (Zantac 360º Maximum Strength) can act fast, with significantly more patients reporting complete relief of heartburn within 1 hour vs. placebo (p<0.001, 20mg; p<0.004, 10 mg)1.

Famotidine Controls Gastric pH for up to 12 Hours

*Among generic acid reducer recommendations.
†Acid control does not correlate to symptom relief.
 

Zantac 360º Is Different Than PPIs and Antacids

There are three over-the-counter therapeutic classes of medicine for heartburn: H2 receptor antagonists (like Zantac 360º), Proton Pump Inhibitors (PPIs), and antacids. They all work differently and only H2 receptor antagonists are indicated to prevent heartburn. As an H2 receptor antagonist, Zantac 360° offers the best of both worlds; one dose of famotidine can prevent or relieve heartburn and can control stomach acid longer than an antacid2,9 and provide faster relief than a PPI.*10

These three OTC options offer distinct and different benefits for your patients. Antacids act rapidly to neutralize stomach acid but have a short duration and cannot prevent heartburn. PPIs inhibit the gastric proton pump to control stomach acid, but they are not intended for immediate relief (it may take 1-4 days for full effect) and are to be taken daily for 14 days.

Zantac 360°, an H2 receptor antagonist with famotidine, is flexible. Available in multiple strengths, Zantac 360º may be taken before or after the onset of heartburn symptoms, empowering your patients to control their occasional heartburn when they need to.

*Based on product labeling, PPIs may take 1 to 4 days for full effect.

Compare Zantac 360º

 

Patient Benefits

H2 Receptor Antagonists

Zantac 360°®, Tagamet®, Pepcid®

Proton Pump Inhibitors

Nexium® 24HR, Prilosec OTC®, Prevacid® 24HR

Antacids

 

Tums®, Rolaids®

For Occasional/Infrequent Heartburn

Yes

No

Yes

Treats Frequent Heartburn

No

Yes

No

Prevents Heartburn

Yes

No

No

Fast Relief of Heartburn

Yes

No

Yes

Long-Lasting Acid Control*

Yes

Yes

No

Indicated for Adults and Children 12 and Older

Yes

No†

Yes

*Acid control does not correlate to symptom relief.
†OTC PPIs are only indicated for adults 18 years of age and older.
All third-party trademarks are trademarks of their respective owners.

References

  1. Lopez, He, and Korvick. (2002) Medical Officer’s Clinical Efficacy Review. NDA 20-325/S-015. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/020325_S015_PEPCID%20AC%20TABLETS_BIOPHARMR.pdf
  2. Feldman (1996) Comparison of the effects of over-the-counter famotidine and calcium carbonate antacid on postprandial gastric acid. JAMA. Vol 275: 1428-1431
  3. Reilly, et al (1995) Low dose famotidine and cimetidine in single postprandial doses: a placebo controlled comparative study of overnight pH. Gut. Vol 37: 325-328
  4. Reilly, et al (1998) Low-dose famotidine and effervescent cimetidine in healthy subjects: a placebo-controlled overnight pH study. Ailment Pharmacol Ther. Vol 12: 469-474
  5. Ryan, et al (1986) Comparison of effects of oral and intravenous famotidine on inhibition of nocturnal gastric acid secretion. The American Journal of Medicine. Vol 81: 60-84
  6. Hamilton, et al (2001) Control of intragastric acidity with over-the-counter doses of ranitidine or famotidine. Ailment Pharmacol Ther. Vol 15: 1579-1583
  7. Smith, et al (1985) Famotidine, a New H2-Receptor Antagonist. Effect on parietal, nonparietal, and pepsin secretion in man. Digestive Diseases and Science. Vol 30: 308-312
  8. Smith (1986) Clinical Pharmacology of Famotidine. Digestion. Vol 32: 15-23
  9. Konturek, et al (2007) The efficacy of hydrotalcite compared with OTC famotidine in the on-demand treatment of gastroesophageal reflux disease: a non-inferiority trial. Med Sci Monit. Vol 13(1): CR44-49
  10. Miner, et al (2006) Comparison of gastric pH with omeprazole magnesium 20.6 mg (Prilosec OTC®) o.m. famotidine 10mg (Pepcid AC®) b.d. and famotidine 20 mg b.d. over 14 days of treatment. Ailment Pharmacol Ther. Vol 25: 103-109
  11. Shaker, et al (2003) Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. The American Journal of Gastroenterology. Vol 98: 1487-1493.

Zantac 360º Is Different Than PPIs and Antacids

There are three over-the-counter therapeutic classes of medicine for heartburn: H2 receptor antagonists (like Zantac 360º), Proton Pump Inhibitors (PPIs), and antacids. They all work differently and only H2 receptor antagonists are indicated to prevent heartburn. As an H2 receptor antagonist, Zantac 360° offers the best of both worlds; one dose of famotidine can prevent or relieve heartburn and can control stomach acid longer than an antacid2,9 and provide faster relief than a PPI.*10

These three OTC options offer distinct and different benefits for your patients. Antacids act rapidly to neutralize stomach acid but have a short duration and cannot prevent heartburn. PPIs inhibit the gastric proton pump to control stomach acid, but they are not intended for immediate relief (it may take 1-4 days for full effect) and are to be taken daily for 14 days.

Zantac 360°, an H2 receptor antagonist with famotidine, is flexible. Available in multiple strengths, Zantac 360º may be taken before or after the onset of heartburn symptoms, empowering your patients to control their occasional heartburn when they need to.

*Based on product labeling, PPIs may take 1 to 4 days for full effect.

Compare Zantac 360º vs PPIs

 

Patient Benefits

H2 Receptor Antagonists

Zantac 360°®, Tagamet®, Pepcid®

Proton Pump Inhibitors

Nexium® 24HR, Prilosec OTC®, Prevacid® 24HR

For Occasional/Infrequent Heartburn

Yes

No

Treats Frequent Heartburn

No

Yes

Prevents Heartburn

Yes

No

Fast Relief of Heartburn

Yes

No

Long-Lasting Acid Control*

Yes

Yes

Indicated for Adults and Children 12 and Older

Yes

No†

Compare Zantac 360º vs Antacids

 

Patient Benefits

H2 Receptor Antagonists

Zantac 360°®, Tagamet®, Pepcid®

Antacids

 

Tums®, Rolaids®

For Occasional/Infrequent Heartburn

Yes

Yes

Treats Frequent Heartburn

No

No

Prevents Heartburn

Yes

No

Fast Relief of Heartburn

Yes

Yes

Long-Lasting Acid Control*

Yes

No

Indicated for Adults and Children 12 and Older

Yes

Yes


*Acid control does not correlate to symptom relief.
†OTC PPIs are only indicated for adults 18 years of age and older.
All third-party trademarks are trademarks of their respective owners.

References

  1. Lopez, He, and Korvick. (2002) Medical Officer’s Clinical Efficacy Review. NDA 20-325/S-015. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/020325_S015_PEPCID%20AC%20TABLETS_BIOPHARMR.pdf
  2. Feldman (1996) Comparison of the effects of over-the-counter famotidine and calcium carbonate antacid on postprandial gastric acid. JAMA. Vol 275: 1428-1431
  3. Reilly, et al (1995) Low dose famotidine and cimetidine in single postprandial doses: a placebo controlled comparative study of overnight pH. Gut. Vol 37: 325-328
  4. Reilly, et al (1998) Low-dose famotidine and effervescent cimetidine in healthy subjects: a placebo-controlled overnight pH study. Ailment Pharmacol Ther. Vol 12: 469-474
  5. Ryan, et al (1986) Comparison of effects of oral and intravenous famotidine on inhibition of nocturnal gastric acid secretion. The American Journal of Medicine. Vol 81: 60-84
  6. Hamilton, et al (2001) Control of intragastric acidity with over-the-counter doses of ranitidine or famotidine. Ailment Pharmacol Ther. Vol 15: 1579-1583
  7. Smith, et al (1985) Famotidine, a New H2-Receptor Antagonist. Effect on parietal, nonparietal, and pepsin secretion in man. Digestive Diseases and Science. Vol 30: 308-312
  8. Smith (1986) Clinical Pharmacology of Famotidine. Digestion. Vol 32: 15-23
  9. Konturek, et al (2007) The efficacy of hydrotalcite compared with OTC famotidine in the on-demand treatment of gastroesophageal reflux disease: a non-inferiority trial. Med Sci Monit. Vol 13(1): CR44-49
  10. Miner, et al (2006) Comparison of gastric pH with omeprazole magnesium 20.6 mg (Prilosec OTC®) o.m. famotidine 10mg (Pepcid AC®) b.d. and famotidine 20 mg b.d. over 14 days of treatment. Ailment Pharmacol Ther. Vol 25: 103-109
  11. Shaker, et al (2003) Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. The American Journal of Gastroenterology. Vol 98: 1487-1493.

Answers to Frequently Asked Questions

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Education & Resources

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