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Heartburn Treatment Options

Many people have used home remedies like aloe or chamomile tea to treat heartburn. But those may not always work for you. Heartburn is different for everyone, and there are a variety of over-the-counter (OTC) heartburn treatment options available to get relief.

Read about different types of heartburn medications below to find out which one is right for you. Each type of product works differently in your body and the time to relief varies.

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OTC HEARTBURN TREATMENT OPTIONS
  Antacids Histamine 2 Blockers
(H2 Blockers)
Proton Pump Inhibitor (PPIs)
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Example Rolaids®
Tums®
Zantac® Nexium® 24HR
Prilosec OTC®
Uses Relieves: Heartburn, acid indigestion, sour stomach and upset stomach associated with these symptomsRelieves and Prevents: Heartburn associated with acid indigestion and sour stomach Treats: Frequent heartburn that occurs two or more days a week; not intended for immediate relief
Adult Dosing Chew 2-4 tablets as symptoms occur*

Do not take for more than 14 days unless advised by a doctor
Take 1 tablet up to twice daily as needed

Do not take for more than 14 days unless advised by a doctor
Take 1 capsule every day for 14 days

Do not take for more than 14 days or more often than every 4 months unless directed by a doctor
How it Works Neutralizes stomach acidReduces stomach acid production Blocks acid production
Onset of relief In minutesIn as little as 30 minutes Not intended for immediate relief. May take 1 to 4 days for full effect.
Duration of acid control 1 to 3 hoursUp to 12 hours Up to 24 hours (when used as a daily regimen)
Drug Interactions Ask a doctor or pharmacist before use if you are currently taking a prescription drug. Antacids may interact with certain prescription drugs.No drug interactions listed on Drug Facts Label. Always let your doctor know what medications you are taking. Ask a doctor or pharmacist before use if you are taking
  • warfarin, clopidogrel or cilostazol (blood-thinning medicines)
  • prescription antifungal or anti-yeast medicines
  • digoxin (heart medicine)
  • diazepam (anxiety medicine)
  • tacrolimus or mycophenolate mofetil (immune system medicine)
  • prescription antiretrovirals (medicines for HIV infection)
  • methotrexate (arthritis medicine)
Read package labels for complete drugs facts information and warnings.
Click here to learn more.

Zantac® provides heartburn relief in 30-60 minutes.
Nexium® 24HR is a registered trademark of AstraZeneca AB
Tums® is a registered trademark of GlaxoSmithKline Consumer Healthcare, LP
Prilosec OTC® is a registered trademark of Procter & Gamble
*based on product strength and directions

About Heartburn

Heartburn is very common — 60 million Americans suffer from heartburn6. Heartburn can be bothersome and disruptive.


  • What Is Heartburn?
  • Common symptoms
  • Common causes of heartburn
  • Tips to prevent heartburn
  • Heartburn Treatment Options
    • Because heartburn is different for everyone, there are a variety of over-the-counter treatment options available to relieve your heartburn. Read about different types of heartburn medications below to find out which one is right for you. Each type of product works differently in your body and the time to relief varies.

      Antacids

      • Indication:
      • Food/Beverage induced heartburn
      • Uses:
      • Relieve heartburn
      • Adult Dosing:
      • Take as directed on package labeling
      • Onset of relief:
      • In minutes
      • Duration:
      • 2 to 3 hours
        (relief may be temporary and require redosing)
      • Examples: Tums®

      Histamine 2 Blockers
      (H2 Blockers)

      • Indication:
      • Food/Beverage induced heartburn
      • Uses:
      • Prevent heartburn, Relieve heartburn
      • Adult Dosing:
      • 1 tablet up to twice daily as needed (not to exceed 14 days of continuous use or see a doctor if you need to take for more than 14 days)
      • Onset of relief:
      • In as little as 30 minutes2
      • Duration:
      • Up to 12 hours

      Proton Pump Inhibitor (PPIs)

      • Indication:
      • Frequent heartburn
        (occurs two or more days a week)
      • Uses:
      • Prevent heartburn
      • Adult Dosing:
      • Taken daily
        (requires a 14 day course of treatment)
      • Onset of relief:
      • Not intended for immediate relief
        (may take 1 to 4 days for full effect)
      • Duration:
      • Up to 24 hours (when used as a daily regimen)
      • Examples: Nexium® 24HR
        Prilosec OTC®
        Prevacid® 24HR
      Tums® is a registered trademark of GlaxoSmithKline Consumer Healthcare, L.P., Nexium® 24HR is a registered trademark of Pfizer Inc., Prilosec OTC® is a registered trademark of Procter & Gamble, Prevacid® 24HR is a registered trademark of Novartis Consumer Health, Inc.